1,2,3-Trimethoxybenzene → 2,3,4-trimethoxybenzenesulfonyl Chloride

HRID 1370573Notes

Reaction equation

HRID 1370573 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:7]([O:8][CH3:9])[C:4]=1[O:5][CH3:6].[Cl:13][S:14](O)(=[O:16])=[O:15]>C(Cl)(Cl)Cl>[CH3:9][O:8][C:7]1[C:4]([O:5][CH3:6])=[C:3]([O:2][CH3:1])[CH:12]=[CH:11][C:10]=1[S:14]([Cl:13])(=[O:16])=[O:15]

Participants

4

Reactant 2

HCID 124621,2,3-TrimethoxybenzeneHCID 24638Chlorosulfonic acid

Product 1

HCID 47127422,3,4-trimethoxybenzenesulfonyl Chloride

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

2,3,4-Trimethoxybenzenesulfonyl chloride is synthesized by reaction of pyrogallol trimethyl ether with chlorosulfonic acid in chloroform at 0° C. according to the procedure described in G. Pifferi and R. Monguzzi, Journal of Pharmaceutical Sciences, 1973, 62, 1393.

Sources & evidence

ORD record
ord-fb0d33638d034a34a47f07c3fa4693de
Source dataset
uspto-grants-2003_06
Patent number
US06583161B1

Reaction notes

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