HCID 86590075, compound → HCID 18752895, compound

HRID 1370581Notes

Reaction equation

HRID 1370581 reaction equation
[NH2:1][C:2]1[C:7](/[CH:8]=[CH:9]/[C:10]([O:12]C(C)(C)C)=[O:11])=[CH:6][C:5]([Cl:17])=[CH:4][N:3]=1>FC(F)(F)C(O)=O.C1(C)C=CC=CC=1>[NH2:1][C:2]1[C:7](/[CH:8]=[CH:9]/[C:10]([OH:12])=[O:11])=[CH:6][C:5]([Cl:17])=[CH:4][N:3]=1

Participants

4

Reactant 1

HCID 86590075HCID 86590075, compound

Product 1

HCID 18752895HCID 18752895, compoundYield 76.9%

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

t-Butyl (E)-3-(2-amino-5-chloro-3-pyridinyl)-2-propenoate (2 g, 7.8 mmol), was stirred in 3 ml of trifluoroacetic acid at ambient temperature for 1 hour. The reaction mixture was diluted with toluene, evaporated to dryness, and the residue triturated with diethyl ether to yield the title compound as a pale yellow solid (1.89 g, 6.0 mmol).

Workup

  1. customevaporated to dryness
  2. customthe residue triturated with diethyl ether

Sources & evidence

ORD record
ord-efc579d9a2384d328dcbac1bbe79eb46
Source dataset
uspto-grants-2003_06
Patent number
US06583162B1

Reaction notes

Loading…