2-Vinylpyridine → HCID 18511695, compound

HRID 1370589Notes

Reaction equation

HRID 1370589 reaction equation
Br[C:2]1[C:3]([NH2:9])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.[CH:10]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=1)=[CH2:11]>>[Cl:8][C:6]1[CH:7]=[C:2](/[CH:11]=[CH:10]/[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[C:3]([NH2:9])=[N:4][CH:5]=1

Participants

3

Reactant 2

HCID 75212-VinylpyridineHCID 27639713-Bromo-5-chloropyridin-2-amine

Product 1

HCID 18511695HCID 18511695, compound

Procedure

The title compound was prepared from 3-bromo-5-chloro-2-pyridinamine and 2-vinylpyridine. Purification by column chromatography on silica gel eluting with methylene chloride—methanol (95:5) and repeated using hexane—EtOAc (70:30 to 50:50) as eluant gave a yellow solid:

Workup

  1. customPurification by column chromatography on silica gel eluting with methylene chloride—methanol (95:5)
  2. customgave a yellow solid

Sources & evidence

ORD record
ord-04df18f8f389442984e1312b3b75dfb4
Source dataset
uspto-grants-2003_06
Patent number
US06583162B1

Reaction notes

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