HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Ethenylbenzonitrile → 3-[(E)-2-(2-Amino-5-chloro-3-pyridinyl)ethenyl]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Ethenylbenzonitrile | HCID 220543 | — |
| Reactant | 3-Bromo-5-chloropyridin-2-amine | HCID 2763971 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-[(E)-2-(2-Amino-5-chloro-3-pyridinyl)ethenyl]benzonitrile | HCID 18752908 | — |
Reaction Steps
The title compound was prepared from 3-bromo-5-chloro-2-pyridinamine and 3-cyanostyrene. Methylene chloride extracts of the crude reaction mixture were concentrated and the desired product purified by column chromatography on silica gel eluting with methylene chloride—methanol (98:2) to give a yellow solid:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06583162B1 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-5288ea3323c94fdcb98ad9caf0210fb7 |
| Source note | uspto-grants-2003_06 |