2-Amino-5-methylpyridine → HCID 10160478, compound

HRID 1370711Notes

Reaction equation

HRID 1370711 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][N:3]=1.[CH:9]1([CH2:15][C@H:16]([N:20]2[C:24](=[O:25])[C@H:23]([CH2:26][CH:27]3[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]3)[NH:22][C:21]2=[O:33])[C:17](O)=[O:18])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1>>[CH:9]1([CH2:15][C@H:16]([N:20]2[C:24](=[O:25])[C@H:23]([CH2:26][CH:27]3[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]3)[NH:22][C:21]2=[O:33])[C:17]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][N:3]=2)=[O:18])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 153482-Amino-5-methylpyridineHCID 67483652HCID 67483652, compound

Product 1

HCID 10160478HCID 10160478, compound

Procedure

By using the conditions described in Step (iv) of Example 17, 2-amino-5-methylpyridine was condensed with (S,S)-3-cyclohexyl-2-[4-(cyclohexyl)methyl-2,5-dioxoimidazolidinyl]propanoic acid [Example 17, Step (iii)] to give the title compound as a colorless foam: EI-HRMS m/e calcd. for C25H36N4O3 (M+) 441.2866, found 441.2869.

Sources & evidence

ORD record
ord-ad74d7d2be254152b358fe6003f54a8d
Source dataset
uspto-grants-2003_06
Patent number
US06583288B2

Reaction notes

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