反应详情

温度

60 °C

A suspension of 168 mg (0.4 mmol) of Compound 25 and 111 mg (1.6 mmol) of hydroxylamine hydrochloride in 10 ml of pyridine was stirred for 21 hours over an oil bath of 60° C. Post-treatment was conducted in a similar manner as in Example 18. The residue was purified by chromatography on a silica gel column (eluent: methanol/chloroform=1/99), whereby 144 mg of the title compound were obtained (yield: 83%).

1. customThe residue was purified by chromatography on a silica gel column (eluent: methanol/chloroform=1/99)