Hydroxyamine hydrochloride → HCID 59071619, compound

HRID 1370730Notes

Reaction equation

HRID 1370730 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][N:17]3[C:21]4[CH2:22][CH2:23][CH2:24][N:25]([CH3:29])[S:26](=[O:28])(=[O:27])[C:20]=4[CH:19]=[CH:18]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl.[NH2:31][OH:32].C([O-])(=O)C.[Na+]>CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][CH2:16][N:17]3[C:21]4[C:22](=[N:31][OH:32])[CH2:23][CH2:24][N:25]([CH3:29])[S:26](=[O:28])(=[O:27])[C:20]=4[CH:19]=[CH:18]3)[CH2:12][CH2:13]2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 22714957HCID 22714957, compound

Product 1

HCID 59071619HCID 59071619, compoundYield 66.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 174 mg (0.4 mmol) of Compound 26, 56 mg (0.8 mmol) of hydroxylamine hydrochloride and 66 mg (0.8 mmol) of sodium acetate in 20 ml of methanol was refluxed for 17 hours. Post-treatment and purification were conducted in a similar manner as in Example 20, whereby 119 mg of the title compound were obtained (yield: 66%).

Workup

  1. temperaturewas refluxed for 17 hours
  2. customPost-treatment and purification

Sources & evidence

ORD record
ord-f5529514d14540dca0a15c9ecc3365cf
Source dataset
uspto-grants-2003_06
Patent number
US06583296B2

Reaction notes

Loading…