Hydrochloric Acid → HCID 131723934, compound

HRID 1370737Notes

Reaction equation

HRID 1370737 reaction equation
C([NH:4][C@H:5]([C:23]([OH:25])=[O:24])[CH2:6][S:7]([C:10]1[CH:15]=[CH:14][C:13]([S:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:12][CH:11]=1)(=[O:9])=[O:8])(=O)C.[ClH:26]>C(O)(=O)C>[ClH:26].[C:17]1([S:16][C:13]2[CH:14]=[CH:15][C:10]([S:7]([CH2:6][C@@H:5]([C:23]([OH:25])=[O:24])[NH2:4])(=[O:9])=[O:8])=[CH:11][CH:12]=2)[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70015288HCID 70015288, compound

Product 1

HCID 131723934HCID 131723934, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of the title compound of Example 11c (30.0 g) in glacial acetic acid (100 mL) and concentrated HCl (100 mL) was heated to 11 degrees C. for 19 hours. The solution was concentrated and trituration with diethyl ether yielded the title compound as a white solid (17.1 g, 78% for 3 steps): Anal. Calcd. for C15H15NO4S2.1.1 HCl.0.25 H2O: C, 47.16; H, 4.38; N, 3.67; Cl, 10.21. Found: C, 47.16; H, 4.27; N, 3.91; Cl, 9.95.

Workup

  1. concentrationThe solution was concentrated

Sources & evidence

ORD record
ord-c722d942a4a948b4a93b2c35cc67f7ad
Source dataset
uspto-grants-2003_06
Patent number
US06583299B1

Reaction notes

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