Potassium Carbonate → HCID 9835703, compound

HRID 1370758Notes

Reaction equation

HRID 1370758 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[C:13](O)[CH:12]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[C:19](=[O:22])([O-])[O-].[K+].[K+].[I-].[CH4:26]>CC(CC)=O>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:26])=[C:13]([O:22][CH3:19])[CH:12]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 18513227HCID 18513227, compoundHCID 20975526HCID 20975526, compound

Product 1

HCID 9835703HCID 9835703, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Conditions

Temperature
100 °C

Procedure

4′-methanesulfonyl-biphenyl-3,4-diol (30 mg) and potassium carbonate (38 mg) were dissolved in methylethylketone. Afterward, methane iodide (0.021 ml) was added and refluxed for 3 hours at 100° C. After filtering just potassium carbonate, the residue was separated through a silica gel attributed chromatography (an eluting agent: ethylacetate/n-hexane=1/4, v/v). As a result, the present compound (22 mg, productive yield 60%) was obtained.

Workup

  1. filtrationAfter filtering just potassium carbonate
  2. customthe residue was separated through a silica gel
  3. customAs a result, the present compound (22 mg, productive yield 60%) was obtained

Sources & evidence

ORD record
ord-a21b8202194e4365a95f84eb17afb66d
Source dataset
uspto-grants-2003_06
Patent number
US06583321B1

Reaction notes

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