反应详情

温度

100 °C

4′-methanesulfonyl-biphenyl-3,4-diol (30 mg) and potassium carbonate (38 mg) were dissolved in methylethylketone. Afterward, methane iodide (0.021 ml) was added and refluxed for 3 hours at 100° C. After filtering just potassium carbonate, the residue was separated through a silica gel attributed chromatography (an eluting agent: ethylacetate/n-hexane=1/4, v/v). As a result, the present compound (22 mg, productive yield 60%) was obtained.

1. filtrationAfter filtering just potassium carbonate
2. customthe residue was separated through a silica gel
3. customAs a result, the present compound (22 mg, productive yield 60%) was obtained