HCID 18511975, compound → HCID 18512254, compound

HRID 1370803Notes

Reaction equation

[CH2:1]([N:8]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28](OC)=[O:29])=[CH:24][CH:23]=1)[C:9]1[C:10]([CH3:20])=[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].C([Al+]CC(C)C)C(C)C>>[CH2:1]([N:8]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([CH2:28][OH:29])=[CH:24][CH:23]=1)[C:9]1[C:10]([CH3:20])=[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 18511975HCID 18511975, compound

HCID 21225700Diisobutylaluminumhydride

Product 1

HCID 18512254HCID 18512254, compound

Procedure

The product from Example 6D and diisobutylaluminum hydride were processed as described in Example 38A to provide the title compound. 1H NMR (300 MHz, CDCl3) δ7.21 (m, 10H), 7.97 (t, J=8.0 Hz, 1H), 6.88 (dd, J=8.5, 1.0 Hz, 1H), 6.12 (s, 1H), 4.67 (d, J=8 Hz, 2H), 4.05 (s, 2H), 4.03 (s, 2H), 2. 96 (s, 3H), 2.37 (s, 2H; MS (APCI+) m/z 411 (M+H)+.

Sources & evidence

ORD record: ord-685c91c2673d4fb2b0ea27c07ff31b10
Source dataset: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06583180B2

Reaction notes

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