1-Iodopropane → N-(2,4-difluorobenzyl)-2-methyl-3-nitro-N-(4-propoxybenzyl)aniline

HRID 1370807Notes

Reaction equation

HRID 1370807 reaction equation
[F:1][C:2]1[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][C:3]=1[CH2:4][N:5]([CH2:16][C:17]1[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[C:7]=1[CH3:15].I[CH2:30][CH2:31][CH3:32]>>[F:1][C:2]1[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][C:3]=1[CH2:4][N:5]([CH2:16][C:17]1[CH:22]=[CH:21][C:20]([O:23][CH2:30][CH2:31][CH3:32])=[CH:19][CH:18]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[C:7]=1[CH3:15]

Participants

3

Reactant 2

HCID 336431-IodopropaneHCID 18512160N-(2,4-difluorobenzyl)-N-(4-hydroxybenzyl)-2-methyl-3-nitroaniline

Product 1

HCID 18512062N-(2,4-difluorobenzyl)-2-methyl-3-nitro-N-(4-propoxybenzyl)aniline

Procedure

The product from Example 33A and 1-iodopropane were processed as described in Example 33B to provide the title compound.

Sources & evidence

ORD record
ord-2755550016e44adb9fee05e62181eec1
Source dataset
uspto-grants-2003_06
Patent number
US06583180B2

Reaction notes

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