3-Amino-1-propanol → HCID 18512363, compound

HRID 1370914Notes

Reaction equation

HRID 1370914 reaction equation
[CH2:1]([N:8]([CH2:21][C:22]1[CH:39]=[CH:38][C:25]([O:26][C:27]2[CH:32]=[CH:31][C:30]([CH2:33][CH2:34][C:35]([OH:37])=O)=[CH:29][CH:28]=2)=[CH:24][CH:23]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[C:10]=1[CH3:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:40][CH2:41][CH2:42][CH2:43][OH:44]>>[CH2:1]([N:8]([CH2:21][C:22]1[CH:39]=[CH:38][C:25]([O:26][C:27]2[CH:32]=[CH:31][C:30]([CH2:33][CH2:34][C:35]([NH:40][CH2:41][CH2:42][CH2:43][OH:44])=[O:37])=[CH:29][CH:28]=2)=[CH:24][CH:23]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[C:10]=1[CH3:20])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 18511931HCID 18511931, compound

Product 1

HCID 18512363HCID 18512363, compound

Procedure

The product from Example 104A and 3-amino-1-propanol were processed as described in Example 147 to provide the title compound. 1H NMR (500 MHz, DMSO-D6) δ ppm 8.95 (s, 1 H), 7.75 (t, 1 H), 7.26 (m, 6 H), 7.19 (m, 3 H), 7.04 (t, 1 H), 6.96 (m, 2 H), 6.87 (m, 4 H), 4.05 (s, 2 H), 4.01 (s, 2 H), 3.35 (m, 2 H), 3.07 (dd, 2 H), 2.91 (s, 3 H), 2.78 (t, 2 H), 2.39 (s, 3 H), 2.34 (t, 2 H), 1.50 (m, 2 H); MS (ESI+) m/z 602 (M+H)+.

Sources & evidence

ORD record
ord-6f860d8174984410b6d7445dd19beba3
Source dataset
uspto-grants-2003_06
Patent number
US06583180B2

Reaction notes

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