6-Amino-1-hexanol → HCID 18512319, compound

HRID 1370916Notes

Reaction equation

HRID 1370916 reaction equation
[CH2:1]([N:8]([CH2:21][C:22]1[CH:39]=[CH:38][C:25]([O:26][C:27]2[CH:32]=[CH:31][C:30]([CH2:33][CH2:34][C:35](O)=[O:36])=[CH:29][CH:28]=2)=[CH:24][CH:23]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[C:10]=1[CH3:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][OH:47]>>[CH2:1]([N:8]([CH2:21][C:22]1[CH:23]=[CH:24][C:25]([O:26][C:27]2[CH:28]=[CH:29][C:30]([CH2:33][CH2:34][C:35]([NH:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][OH:47])=[O:36])=[CH:31][CH:32]=2)=[CH:38][CH:39]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][S:16]([CH3:19])(=[O:17])=[O:18])[C:10]=1[CH3:20])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 199606-Amino-1-hexanolHCID 18511931HCID 18511931, compound

Product 1

HCID 18512319HCID 18512319, compound

Procedure

The product from Example 104A and 6-amino-1-hexanol processed as described in Example 147 to provide the title compound. 1H NMR (500 MHz, DMSO-D) δ8.95 (s, 1 H), 7.73 (t, 1 H), 7.26 (m, 6 H), 7.19 (m, 3 H), 7.04 (t, 1 H), 6.96 (m, 2 H), 6.87 (m, 4 H), 4.03 (d, 4 H), 3.35 (m, 2 H), 3.00 (dd, 2 H), 2.91 (s, 3 H), 2.78 (t, 2 H), 2.39 (s, 3 H), 2.33 (t, 2 H), 1.37 (m, 4 H), 1.23 (m, 4 H); MS (APCI+) m/z 645 (M+H)+.

Sources & evidence

ORD record
ord-4f784fabaab54984b6c8c4592985f90d
Source dataset
uspto-grants-2003_06
Patent number
US06583180B2

Reaction notes

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