Ethyl 4-piperidinecarboxylate → 1-[4-(3-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenoxy)butanoyl]piperidine-4-carboxylic Acid
Reaction equation
[CH2:1]([N:8]([CH2:21][C:22]1[CH:41]=[CH:40][C:25]([O:26][C:27]2[CH:28]=[C:29]([CH:37]=[CH:38][CH:39]=2)[O:30][CH2:31][CH2:32][CH2:33][C:34]([OH:36])=O)=[CH:24][CH:23]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[C:10]=1[CH3:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:42]1[CH2:52][CH2:51][CH:45]([C:46]([O:48]CC)=[O:47])[CH2:44][CH2:43]1>>[CH2:1]([N:8]([CH2:21][C:22]1[CH:23]=[CH:24][C:25]([O:26][C:27]2[CH:28]=[C:29]([CH:37]=[CH:38][CH:39]=2)[O:30][CH2:31][CH2:32][CH2:33][C:34]([N:42]2[CH2:52][CH2:51][CH:45]([C:46]([OH:48])=[O:47])[CH2:44][CH2:43]2)=[O:36])=[CH:40][CH:41]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[C:10]=1[CH3:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Participants
3
Reactant 2
Product 1
Procedure
The product from Example 116B (57 mg, 0.10 mmole) and ethyl isonipecotate (31 mg, 0.20 mmole) were processed as in Example 279A and B to provide the titled compound. 1H NMR (500 MHz, DMSO-d6 δ12.05-12.35 (br.s, 1 H), 8.95 (s, 1 H), 7.23 (m, 8 H), 7.03 (m, 1 H), 6.94 (m, 4 H), 6.69 (dd, 1 H), 6.49 (m, 2 H), 4.20 (d, 1 H), 4.06 (s, 2 H), 4.03 (s, 2 H), 3.94 (t, 2 H), 3.77 (d, 1 H), 3.05 (t, 1 H), 2.91 (s, 3 H), 2.70 (t, 1 H), 2.47 (m, 1 H), 2.43 (m, 2 H), 2.39 (s, 3 H), 1.90 (m, 2 H), 1.79 (m, 2 H), 1.45 (m, 1 H), 1.34 (m, 1 H); MS (APCI+) m/z 686.4 (M+H)+.
Sources & evidence
- ORD record
- ord-248085a4b55843fb9c86f56e6e978e1c
- Source dataset
- uspto-grants-2003_06
- Patent number
- US06583180B2
Reaction notes
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