Methanesulfonyl chloride → HCID 86586240, compound

HRID 1370975Notes

Reaction equation

HRID 1370975 reaction equation
[NH2:1][C:2]1[C:3]([CH3:39])=[C:4]([N:8]([CH2:17][C:18]2[CH:38]=[CH:37][C:21]([O:22][C:23]3[CH:24]=[CH:25][C:26]([Cl:36])=[C:27]([CH:35]=3)[O:28][CH2:29][C:30]([O:32][CH2:33][CH3:34])=[O:31])=[CH:20][CH:19]=2)[CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[F:16])[CH:5]=[CH:6][CH:7]=1.[CH3:40][S:41](Cl)(=[O:43])=[O:42]>N1C=CC=CC=1>[CH3:2][CH3:7].[Cl:36][C:26]1[CH:25]=[CH:24][C:23]([O:22][C:21]2[CH:37]=[CH:38][C:18]([CH2:17][N:8]([CH2:9][C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[F:16])[C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([NH:1][S:41]([CH3:40])(=[O:43])=[O:42])[C:3]=3[CH3:39])=[CH:19][CH:20]=2)=[CH:35][C:27]=1[O:28][CH2:29][C:30]([O:32][CH2:33][CH3:34])=[O:31]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 86586238Ethyl (5-(4-(((3-amino-2-methylphenyl)(2-fluorobenzyl)amino)methyl)phenoxy)-2-chlorophenoxy)acetate

Product 1

HCID 86586240HCID 86586240, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The product from Example 306C in anhydrous pyridine (1.5 mL) was cooled at 0° C. and treated with methane sulfonyl chloride (0.042 mL, 0.54 mmoles) at 0° C. for 1 hour, then room temperature for 1 hour. The reaction mixture concentrated in vacuo, residue dissolved in dichloromethane, filtered and filtrate concentrated in vacuo to provide the title compound.

Workup

  1. concentrationThe reaction mixture concentrated in vacuo, residue
  2. dissolutiondissolved in dichloromethane
  3. filtrationfiltered
  4. concentrationfiltrate concentrated in vacuo

Sources & evidence

ORD record
ord-2a45ec5b3a6648439ececd5297c975d9
Source dataset
uspto-grants-2003_06
Patent number
US06583180B2

Reaction notes

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