HRID1371020

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)c1ccc(C(Cc2ccc(OC(F)(F)C(=O)OC(C)(C)C)cc2)(Cc2ccc(C(F)(F)P(=O)(OC(C)(C)C)OC(C)(C)C)cc2)C(=O)c2ccc(F)cc2)cc1

HCID18510258

未命名化合物

HCID21863450

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1ccc(C(Cc2ccc(OC(F)(F)C(=O)O)cc2)(Cc2ccc(C(F)(F)P(=O)(O)O)cc2)C(=O)c2ccc(F)cc2)cc1

HCID10168904

未命名化合物

PROCEDURE

实验过程

The compound of Step 2 was treated with TFA/CH2Cl2 (1/1) at r.t. After a period of 18 h, the solvents were evaporated under reduced pressure to give the title compound (racemate).

WORKUP

后处理

customthe solvents were evaporated under reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-12bb4caca81f42748a04c45423d2cae2
来源数据集: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06583126B2
来源说明: uspto-grants-2003_06

反应 SMILES

C([O:5][C:6](=[O:60])[C:7]([F:59])([F:58])[O:8][C:9]1[CH:57]=[CH:56][C:12]([CH2:13][C:14]([C:46]2[CH:55]=[CH:54][C:49]([C:50]([O:52][CH3:53])=[O:51])=[CH:48][CH:47]=2)([CH2:24][C:25]2[CH:30]=[CH:29][C:28]([C:31]([P:34]([O:41]C(C)(C)C)([O:36]C(C)(C)C)=[O:35])([F:33])[F:32])=[CH:27][CH:26]=2)[C:15]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)=[O:16])=[CH:11][CH:10]=1)(C)(C)C.C(O)(C(F)(F)F)=O.C(Cl)Cl>>[F:33][C:31]([F:32])([P:34]([OH:36])([OH:41])=[O:35])[C:28]1[CH:29]=[CH:30][C:25]([CH2:24][C:14]([C:46]2[CH:55]=[CH:54][C:49]([C:50]([O:52][CH3:53])=[O:51])=[CH:48][CH:47]=2)([C:15]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)=[O:16])[CH2:13][C:12]2[CH:56]=[CH:57][C:9]([O:8][C:7]([F:59])([F:58])[C:6]([OH:60])=[O:5])=[CH:10][CH:11]=2)=[CH:26][CH:27]=1