Methyl 4-[1-{4-[2-(tert-butoxy)-1,1-difluoro-2-oxoethoxy]benzyl}-1-{4-[[di(tert-butoxy)phosphoryl](difluoro)methyl]benzyl}-2-(4-fluorophenyl)-2-oxoethyl]benzoate → (4-{-2-{4-[Difluoro(phosphono)methyl]benzyl}-3-(4-fluorophenyl)-2-[4-(methoxycarbonyl)phenyl]-3-oxopropyl}phenoxy)-2,2-difluoroacetic acid

Participants

Role	Name	HCID	Charge
Reactant	Methyl 4-[1-{4-[2-(tert-butoxy)-1,1-difluoro-2-oxoethoxy]benzyl}-1-{4-[[di(tert-butoxy)phosphoryl](difluoro)methyl]benzyl}-2-(4-fluorophenyl)-2-oxoethyl]benzoate	HCID 18510258	—
Reactant	Trifluoroacetic acid methylene chloride	HCID 21863450	—
Product	(4-{-2-{4-[Difluoro(phosphono)methyl]benzyl}-3-(4-fluorophenyl)-2-[4-(methoxycarbonyl)phenyl]-3-oxopropyl}phenoxy)-2,2-difluoroacetic acid	HCID 10168904	—

Reaction Steps

The compound of Step 2 was treated with TFA/CH2Cl2 (1/1) at r.t. After a period of 18 h, the solvents were evaporated under reduced pressure to give the title compound (racemate).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06583126B2
Source dataset	uspto-grants-2003_06
ORD ID	ord-12bb4caca81f42748a04c45423d2cae2
Source note	uspto-grants-2003_06