Sodium Hydroxide → 4-[2-(4-Fluorophenyl)-2-oxoethyl]benzoic acid

Participants

Reaction Steps

To a solution of methyl 4-[2-(4-fluorophenyl)-2-oxoethyl]benzoate (1.00 g, 3.67 mmol) dissoved in ethanol (18 ml) was added sodium hydroxide 2M (18 ml). The mixture was refluxed for 15 minutes The reaction was cooled and evaporated to removed ethanol. The aqueous residue was acidified with HCl 2 M and extracted with ethyl acetate. The organic fraction was dried over sodium sulfate, filtered and evaporated to give (0.9 g) of the title compound.

Provenance & Evidence