Sodium Hydroxide → 4-[2-(4-Fluorophenyl)-2-oxoethyl]benzoic acid

HRID 1371021ノート

反応式

HRID 1371021 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:20])[CH2:9][C:10]2[CH:19]=[CH:18][C:13]([C:14]([O:16]C)=[O:15])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[O:20])[CH2:9][C:10]2[CH:11]=[CH:12][C:13]([C:14]([OH:16])=[O:15])=[CH:18][CH:19]=2)=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 18510220Methyl 4-[2-(4-fluorophenyl)-2-oxoethyl]benzoate

生成物 1

HCID 185102554-[2-(4-Fluorophenyl)-2-oxoethyl]benzoic acid収率 95%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of methyl 4-[2-(4-fluorophenyl)-2-oxoethyl]benzoate (1.00 g, 3.67 mmol) dissoved in ethanol (18 ml) was added sodium hydroxide 2M (18 ml). The mixture was refluxed for 15 minutes The reaction was cooled and evaporated to removed ethanol. The aqueous residue was acidified with HCl 2 M and extracted with ethyl acetate. The organic fraction was dried over sodium sulfate, filtered and evaporated to give (0.9 g) of the title compound.

後処理

  1. temperatureThe mixture was refluxed for 15 minutes The reaction
  2. temperaturewas cooled
  3. customevaporated
  4. customto removed ethanol
  5. extractionextracted with ethyl acetate
  6. dry with materialThe organic fraction was dried over sodium sulfate
  7. filtrationfiltered
  8. customevaporated

出典と根拠

ORDレコード
ord-a2475d705f2642d2ad5742a24d1827f8
出典データセット
uspto-grants-2003_06
特許番号
US06583126B2

反応ノート

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