Sodium Hydroxide → HCID 10305507, compound

HRID 1371032Notes

Reaction equation

HRID 1371032 reaction equation
[F:1][C:2]([F:48])([P:44]([OH:47])([OH:46])=[O:45])[C:3]1[CH:43]=[CH:42][C:6]([CH2:7][C:8]([C:32]2[CH:37]=[CH:36][C:35]([C:38]([O:40]C)=[O:39])=[CH:34][CH:33]=2)([C:23]([C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)=[O:24])[CH2:9][C:10]2[CH:15]=[CH:14][C:13](OP(C(F)F)(=O)O)=[CH:12][CH:11]=2)=[CH:5][CH:4]=1.[OH-:49].[Na+]>C1COCC1.CO>[F:1][C:2]([F:48])([P:44]([OH:46])([OH:45])=[O:49])[C:13]1[CH:14]=[CH:15][C:10]([CH2:9][C:8]([C:32]2[CH:33]=[CH:34][C:35]([C:38]([OH:40])=[O:39])=[CH:36][CH:37]=2)([CH2:7][C:6]2[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:48])[P:44]([OH:47])([OH:46])=[O:45])=[CH:43][CH:42]=2)[C:23]([C:25]2[CH:26]=[CH:27][C:28]([F:31])=[CH:29][CH:30]=2)=[O:24])=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 88104241HCID 88104241, compound

Product 1

HCID 10305507HCID 10305507, compound

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

The compound of Example 10 (0.080 g, 0.112 mmol) was treated with NaOH in THF/MeOH at 60° C. After a period of 18 h, Dowex H+ was added. After a few minutes, the resin was filtered and the solvent evaporated to provide the title compound.

Workup

  1. additionDowex H+ was added
  2. waitAfter a few minutes
  3. filtrationthe resin was filtered
  4. customthe solvent evaporated

Sources & evidence

ORD record
ord-893e565d322648b48f0c99f827a98fa9
Source dataset
uspto-grants-2003_06
Patent number
US06583126B2

Reaction notes

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