反应详情

A mixture of [3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indol-7-yl]-carbamic acid benzyl ester (7.78 g, 18.2 mmol) and 20% palladium hydroxide on carbon (1.6 g) in ethanol is hydrogenated at 50° C. at 60 psi for 18 hours. After filtration of the catalyst the solution is concentrated in vacuo to furnish the title compound as a black solid (5.04 g, 94%). LC-MS m/z 295.1 (M++1).

1. filtrationAfter filtration of the catalyst the solution
2. concentrationis concentrated in vacuo