Piperidin-4-ol → HCID 178433079, compound

HRID 1371216Notes

Reaction equation

HRID 1371216 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[CH3:8][C:9]1[NH:14][C:13]2=[CH:15][C:16]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[N:17][C:12]2=[C:11]([Cl:24])[N:10]=1>>[OH2:1].[ClH:24].[CH3:8][C:9]1[NH:14][C:13]2[C:12]([N:17]=[C:16]([C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:15]=2)=[C:11]([N:5]2[CH2:6][CH2:7][CH:2]([OH:1])[CH2:3][CH2:4]2)[N:10]=1

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 178432852HCID 178432852, compound

Product 1

HCID 178433079HCID 178433079, compound

Procedure

The title compound was prepared according to the procedure described in Example 173, using 4-hydroxy piperidine (Aldrich Chemical Company)(0.26 g, 2.57 mmol) and 2-methyl-4-chloro-6-phenylpyrrolo[3,2-d]pyrimidine (Example 1e) (0.49 g, 2.0 mmol), as a white solid (0.30 g, 48%). 1H NMR (DMSO-d6; 400 MHz): d 1.51-1.59 (m, 2), 2.58 (s, 3), 3.78-3.90 (m, 3), 4.34-4.37 (m, 2), 6.89 (s, 1), 7.49-7.57 (m, 3), 7.96 (d, 2, J=7.2), 11.8 (br s, 1). MS m/z: 308 (M+1). Anal. Calcd for C18H20N4O.HCl.0.33H2O: C, 61.62; H, 5.94; N, 15.97; Cl, 10.10. Found: C, 61.62; H, 5.91; N, 15.81; Cl, 10.28.

Sources & evidence

ORD record
ord-de188126058845a293f15d6b216e0afa
Source dataset
uspto-grants-2003_06
Patent number
US06583154B1

Reaction notes

Loading…