1-Acetylpiperazine → HCID 21070187, compound

HRID 1371279Notes

Reaction equation

Cl[CH2:2][C:3]([NH:5][C:6]1[CH:19]=[CH:18][C:17]2[NH:16][C:15](=[O:20])[C:14]3[C:9]4=[C:10]([CH2:21][C:7]=1[C:8]=24)[CH:11]=[CH:12][CH:13]=3)=[O:4].[N:22]1([C:28](=[O:30])[CH3:29])[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>>[C:28]([N:22]1[CH2:27][CH2:26][N:25]([CH2:2][C:3]([NH:5][C:6]2[CH:19]=[CH:18][C:17]3[NH:16][C:15](=[O:20])[C:14]4[C:9]5=[C:10]([CH2:21][C:7]=2[C:8]=35)[CH:11]=[CH:12][CH:13]=4)=[O:4])[CH2:24][CH2:23]1)(=[O:30])[CH3:29]

Participants

Reactant 2

HCID 837951-Acetylpiperazine

HCID 58777502HCID 58777502, compound

Product 1

HCID 21070187HCID 21070187, compoundYield 58%

Procedure

Prepared from the reaction of 2-chloro-N-(5-oxo-5,9-dihydro-4H-cyclopenta[lmn]phenanthridin-1-yl)-acetamide 8 and 1-piperazin-1-yl-ethanone (0.1 mL) according to General Procedure B. White solid in 58% yield, mp155–157° C. 1H-NMR (300 MHz, DMSO-d6) □ 11.44(s, 1H); 9.85(s, 1H); 7.93(d, 2H); 7.61(m, 2H); 7.13(d, 1H, J=8.2 Hz); 4.25(s, 2H); 3.56(s, 4H); 3.24(s, 2H); 2.57(s, 2H); 2.54(s, 2H); 2.02(s, 3H). Anal (C22H22N2O3 1.3 H2O) C H N.

Sources & evidence

ORD record: ord-acb7b2e5013d46fe8babdf75ae9790f5
Source dataset: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07157452B2

Reaction notes

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