Phenyl isocyanate → HCID 22479008, compound

HRID 1371326Notes

Reaction equation

HRID 1371326 reaction equation
[CH2:1]([C:7]1[N:8]([CH2:20][CH2:21][CH2:22][CH2:23][NH2:24])[C:9]2[C:18]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[N:12]=[CH:11][C:10]=2[N:19]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[C:25]1([N:31]=[C:32]=[O:33])[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[CH2:1]([C:7]1[N:8]([CH2:20][CH2:21][CH2:22][CH2:23][NH:24][C:32]([NH:31][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[O:33])[C:9]2[C:18]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[N:12]=[CH:11][C:10]=2[N:19]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

3

Reactant 2

HCID 7672Phenyl isocyanateHCID 223444374-(2-Hexyl-1H-imidazo[4,5-c]quinolin-1-yl)butan-1-amine

Product 1

HCID 22479008HCID 22479008, compoundYield 87.4%

Procedure

Using the general method of Example 146. Part B, 4-(2-hexyl-1H-imidazo[4,5-c]quinolin-1-yl)butylamine (4.0 g, 12.3 mmol) was reacted with phenyl isocyanate (1.34 mL, 12.3 mmol) to provide 4.77 g of N-[4-(2-hexyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]-N′-phenylurea.

Sources & evidence

ORD record
ord-4f29333fc30d42dd8fa8cc8d60cce8ca
Source dataset
uspto-grants-2007_01
Patent number
US07157453B2

Reaction notes

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