참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Isopropylamine | HCID 6363 | — |
| 반응물 | 3,5-Dibromoimidazo[1,2-a]pyrazine | HCID 14207592 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-Bromo-n-isopropylimidazo[1,2-a]pyrazin-8-amine | HCID 21070914 | 68.1% |
반응 단계
To a solution of 3,5-dibromo-imidazo[1,2-a]pyrazine (D) (200 mg, 0.72 mmol) in THF (3.6 ml) was added isopropylamine (1.3 ml, 14.4 mmol). The mixture was heated at 70° C. overnight. The mixture was then cooled to rt, diluted with DCM. The organic layer was washed with water, brine, dried and concentrated. The residue was purified on a silica gel column to afford 125 mg (yield 68%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07157460B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_01 |
|---|
| ORD ID | ord-9be43ace03fe4d82a55365845439f244 |
|---|
| 출처 메모 | uspto-grants-2007_01 |
|---|
