Isopropylamine → 3-Bromo-n-isopropylimidazo[1,2-a]pyrazin-8-amine

HRID 1371364Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1371364
[Br:1][C:2]1[N:6]2[C:7](Br)=[CH:8][N:9]=[CH:10][C:5]2=[N:4][CH:3]=1.[CH:12]([NH2:15])([CH3:14])[CH3:13]>C1COCC1.C(Cl)Cl>[Br:1][C:2]1[N:6]2[CH:7]=[CH:8][N:9]=[C:10]([NH:15][CH:12]([CH3:14])[CH3:13])[C:5]2=[N:4][CH:3]=1

Komponenten

5

Edukt 2

HCID 6363IsopropylamineHCID 142075923,5-Dibromoimidazo[1,2-a]pyrazine

Produkt 1

HCID 210709143-Bromo-n-isopropylimidazo[1,2-a]pyrazin-8-amineAusbeute 68,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

To a solution of 3,5-dibromo-imidazo[1,2-a]pyrazine (D) (200 mg, 0.72 mmol) in THF (3.6 ml) was added isopropylamine (1.3 ml, 14.4 mmol). The mixture was heated at 70° C. overnight. The mixture was then cooled to rt, diluted with DCM. The organic layer was washed with water, brine, dried and concentrated. The residue was purified on a silica gel column to afford 125 mg (yield 68%) of the title compound.

Aufarbeitung

  1. temperatureThe mixture was then cooled to rt
  2. washThe organic layer was washed with water, brine
  3. customdried
  4. concentrationconcentrated
  5. customThe residue was purified on a silica gel column

Quellen und Nachweise

ORD-Eintrag
ord-9be43ace03fe4d82a55365845439f244
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07157460B2

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