HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 17984664, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl 4-{[({[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}amino)carbonyl]amino}piperidine-1-carboxylate | HCID 17984711 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 17984664 | HCID 17984664 | 175.1% |
Reaction Steps
Intermediate 15 (0.157 g) was stirred in dioxane (4 ml) containing 4.0M hydrogen chloride in dioxane (0.78 ml) for 16 h, at 23° C. under nitrogen. The solvent was removed in vacuo, azeotroped with dichloromethane (20 ml), triturated in ether and dried under vacuum to give the title compound as a pale yellow solid (0.12 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157457B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-ccb0673f839c41068d88f92c37a6d083 |
| Source note | uspto-grants-2007_01 |