HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl 4-({[({[(2S)-4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}amino)carbonyl]amino}methyl)piperidine-1-carboxylate → HCID 69507286, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl 4-({[({[(2S)-4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}amino)carbonyl]amino}methyl)piperidine-1-carboxylate | HCID 69507185 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 69507286 | HCID 69507286 | 268% |
Reaction Steps
Intermediate 17 (0.390 g) was stirred in 4.0M hydrogen chloride in dioxane (4 ml) for 2 h, at 23° C. under nitrogen. The solvent was removed in vacuo, azeotroped with dichloromethane (20 ml), and dried under vacuum to give the title compound as a pale yellow solid, (0.33 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157457B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-831c3995610342df8a7810b329294ee9 |
| Source note | uspto-grants-2007_01 |