tert-butyl 4-({[({[(2S)-4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}amino)carbonyl]amino}methyl)piperidine-1-carboxylate → HCID 69507286, compound

HRID 1371388Notes

Reaction equation

HRID 1371388 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:31]=[CH:32][C:33]=1[Cl:34])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][C@@H:8]([CH2:12][NH:13][C:14]([NH:16][CH2:17][CH:18]2[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]2)=[O:15])[CH2:7]1>Cl.O1CCOCC1>[ClH:1].[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:31]=[CH:32][C:33]=1[Cl:34])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][C@@H:8]([CH2:12][NH:13][C:14]([NH:16][CH2:17][CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)=[O:15])[CH2:7]1

Participants

4

Reactant 1

HCID 69507185tert-butyl 4-({[({[(2S)-4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}amino)carbonyl]amino}methyl)piperidine-1-carboxylate

Product 1

HCID 69507286HCID 69507286, compoundYield 268%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

Intermediate 17 (0.390 g) was stirred in 4.0M hydrogen chloride in dioxane (4 ml) for 2 h, at 23° C. under nitrogen. The solvent was removed in vacuo, azeotroped with dichloromethane (20 ml), and dried under vacuum to give the title compound as a pale yellow solid, (0.33 g).

Workup

  1. customThe solvent was removed in vacuo
  2. customazeotroped with dichloromethane (20 ml)
  3. customdried under vacuum

Sources & evidence

ORD record
ord-831c3995610342df8a7810b329294ee9
Source dataset
uspto-grants-2007_01
Patent number
US07157457B2

Reaction notes

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