Tetrahydrofuran → (9-((5-(2-Hydroxyethyl)thiophen-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-methylthiazol-4-yl)methanone

HRID 137140Notes

Reaction equation

HRID 137140 reaction equation
[C:1]([Si:2]([CH3:3])([CH3:4])[O:6][CH2:7][CH2:8][c:9]1[cH:10][cH:11][c:12]([CH2:14][N:15]2[CH2:16][CH2:17][C:18]3([CH2:19][N:20]([C:24](=[O:25])[c:26]4[n:27][c:28]([CH3:31])[s:29][cH:30]4)[CH2:21][CH2:22][O:23]3)[CH2:32][CH2:33]2)[s:13]1)([CH3:5])([CH3:34])[CH3:35].[CH2:54]1[O:55][CH2:56][CH2:57][CH2:58]1.[CH3:37][CH2:38][CH2:39][CH2:40][N+:41]([CH2:42][CH2:43][CH2:44][CH3:45])([CH2:46][CH2:47][CH2:48][CH3:49])[CH2:50][CH2:51][CH2:52][CH3:53].[F-:36]>>[OH:6][CH2:7][CH2:8][c:9]1[cH:10][cH:11][c:12]([CH2:14][N:15]2[CH2:16][CH2:17][C:18]3([CH2:19][N:20]([C:24](=[O:25])[c:26]4[n:27][c:28]([CH3:31])[s:29][cH:30]4)[CH2:21][CH2:22][O:23]3)[CH2:32][CH2:33]2)[s:13]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 57989061(9-((5-(2-(tert-Butyldimethylsilyloxy)ethyl)thiophen-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-methylthiazol-4-yl)methanone

Product 1

HCID 57989315(9-((5-(2-Hydroxyethyl)thiophen-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-methylthiazol-4-yl)methanone

Sources & evidence

ORD record
ord-ecc049f9f17f4e94915500127c01dbdb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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