Methyl 3-isocyanatobenzoate → HCID 10138895, compound

HRID 1371415Notes

Reaction equation

HRID 1371415 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[N:18]([C:21]1[CH:22]=[C:23]([CH:28]=[CH:29][CH:30]=1)[C:24]([O:26][CH3:27])=[O:25])=[C:19]=[O:20]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:19]([NH:18][C:21]2[CH:22]=[C:23]([CH:28]=[CH:29][CH:30]=2)[C:24]([O:26][CH3:27])=[O:25])=[O:20])[CH2:7]1

Participants

3

Reactant 2

HCID 2733366Methyl 3-isocyanatobenzoateHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 10138895HCID 10138895, compoundYield 90%

Procedure

Example 15 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 3 (0.025 g) and methyl 3-isocyanatobenzoate (0.0241 g) to give the title compound (0.037 g). LC-MS (System A): Rt 2.32 mins, Mass Spectrum m/z 452 [MH+].

Workup

  1. customExample 15 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-c7da920a9c7943cbb4c170e761718f4d
Source dataset
uspto-grants-2007_01
Patent number
US07157457B2

Reaction notes

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