3-(Methylthio)phenyl isocyanate → N-{[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}-N'-[3-(methylthio)phenyl]urea

HRID 1371418Notes

Reaction equation

HRID 1371418 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[N:18]([C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([S:27][CH3:28])[CH:22]=1)=[C:19]=[O:20]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:19]([NH:18][C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([S:27][CH3:28])[CH:22]=2)=[O:20])[CH2:7]1

Participants

3

Reactant 2

HCID 1414183-(Methylthio)phenyl isocyanateHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 17984662N-{[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}-N'-[3-(methylthio)phenyl]urea

Procedure

Example 18 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 3 (0.025 g) and 1-isocyanato-3-(methylthio)benzene (18.8 μl) to give the title compound (0.0352 g). LC-MS (System A): Rt 2.41 mins, Mass Spectrum m/z 440 [MH+].

Workup

  1. customExample 18 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-c093d6bbb31b49d5ac8cecd49646717b
Source dataset
uspto-grants-2007_01
Patent number
US07157457B2

Reaction notes

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