4-Biphenylyl isocyanate → N-(1,1'-Biphenyl-4-yl)-N'-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}urea

HRID 1371429Notes

Reaction equation

HRID 1371429 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[N:18]([C:21]1[CH:26]=[CH:25][C:24]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:23][CH:22]=1)=[C:19]=[O:20]>>[C:24]1([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:23]=[CH:22][C:21]([NH:18][C:19]([NH:13][CH2:12][CH:8]2[O:9][CH2:10][CH2:11][N:6]([CH2:5][C:4]3[CH:14]=[CH:15][C:16]([Cl:17])=[C:2]([Cl:1])[CH:3]=3)[CH2:7]2)=[O:20])=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 36123194-Biphenylyl isocyanateHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 10227081N-(1,1'-Biphenyl-4-yl)-N'-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}ureaYield 73.5%

Procedure

Example 32 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 3 (0.025 g) and 4-isocyanato-1,1′-biphenyl (0.0266 g) to give the title compound (0.0314 g). LC-MS (System A): Rt 2.65 mins, Mass Spectrum m/z 470 [MH+].

Workup

  1. customExample 32 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-87798fdf420d42bc93b4cc40b32fd4dd
Source dataset
uspto-grants-2007_01
Patent number
US07157457B2

Reaction notes

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