4-Biphenylyl isocyanate → N-(1,1'-Biphenyl-4-yl)-N'-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}urea

Participants

Role	Name	HCID	Charge
Reactant	4-Biphenylyl isocyanate	HCID 3612319	—
Reactant	[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine	HCID 10308229	—
Product	N-(1,1'-Biphenyl-4-yl)-N'-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}urea	HCID 10227081	73.5%

Reaction Steps

Example 32 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 3 (0.025 g) and 4-isocyanato-1,1′-biphenyl (0.0266 g) to give the title compound (0.0314 g). LC-MS (System A): Rt 2.65 mins, Mass Spectrum m/z 470 [MH+].

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07157457B2
Source dataset	uspto-grants-2007_01
ORD ID	ord-87798fdf420d42bc93b4cc40b32fd4dd
Source note	uspto-grants-2007_01