4-(Dimethylamino)phenyl isocyanate → N-{[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}-N'-[4-(dimethylamino)phenyl]urea

HRID 1371433Notes

Reaction equation

HRID 1371433 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[N:18]([C:21]1[CH:29]=[CH:28][C:24]([N:25]([CH3:27])[CH3:26])=[CH:23][CH:22]=1)=[C:19]=[O:20]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:19]([NH:18][C:21]2[CH:29]=[CH:28][C:24]([N:25]([CH3:27])[CH3:26])=[CH:23][CH:22]=2)=[O:20])[CH2:7]1

Participants

3

Reactant 2

HCID 27333724-(Dimethylamino)phenyl isocyanateHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 10181536N-{[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}-N'-[4-(dimethylamino)phenyl]ureaYield 78%

Procedure

Example 36 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 3 (0.025 g) and 4-isocyanato-N,N-dimethylaniline (0.0221 g) to give the title compound (0.031 g). LC-MS (System A): Rt 1.68 mins, Mass Spectrum m/z 437 [MH+].

Workup

  1. customExample 36 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-639f57edf2724baeb93a06bc83371863
Source dataset
uspto-grants-2007_01
Patent number
US07157457B2

Reaction notes

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