2-Chloro-5-(chloromethyl)thiophene → N-(4-Chlorophenyl)-N'-({4-[(5-chlorothien-2-yl)methyl]morpholin-2-yl}methyl)urea

HRID 1371434Notes

Reaction equation

HRID 1371434 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][CH2:12][CH:13]2[O:18][CH2:17][CH2:16][NH:15][CH2:14]2)=[O:10])=[CH:4][CH:3]=1.[Cl:19][C:20]1[S:21][C:22]([CH2:25]Cl)=[CH:23][CH:24]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][CH2:12][CH:13]2[O:18][CH2:17][CH2:16][N:15]([CH2:25][C:22]3[S:21][C:20]([Cl:19])=[CH:24][CH:23]=3)[CH2:14]2)=[O:10])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 5830792-Chloro-5-(chloromethyl)thiopheneHCID 23089254N-(4-Chlorophenyl)-N'-(morpholin-2-ylmethyl)urea

Product 1

HCID 10272295N-(4-Chlorophenyl)-N'-({4-[(5-chlorothien-2-yl)methyl]morpholin-2-yl}methyl)ureaYield 66%

Procedure

Example 37 was prepared in an analogous manner to Example 19 using a mixture of Intermediate 9 (0.01 g) and 2-chloro-5-(chloromethyl)thiophene (0.0068 g) to give the title compound (0.0098 g). LC-MS (System A): Rt 2.84 mins, Mass Spectrum m/z 400 [MH+].

Workup

  1. customExample 37 was prepared in an analogous manner to Example 19 using

Sources & evidence

ORD record
ord-90864ac9f6f846b58ee8c5dec4529ca8
Source dataset
uspto-grants-2007_01
Patent number
US07157457B2

Reaction notes

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