Ethyl bromophenylacetate → Ethyl {2-[({[(4-chlorophenyl)amino]carbonyl}amino)methyl]morpholin-4-yl}(phenyl)acetate

HRID 1371441Notes

Reaction equation

HRID 1371441 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][CH2:12][CH:13]2[O:18][CH2:17][CH2:16][NH:15][CH2:14]2)=[O:10])=[CH:4][CH:3]=1.Br[CH:20]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:21]([O:23][CH2:24][CH3:25])=[O:22]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][CH2:12][CH:13]2[O:18][CH2:17][CH2:16][N:15]([CH:20]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH2:14]2)=[O:10])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 97780Ethyl bromophenylacetateHCID 23089254N-(4-Chlorophenyl)-N'-(morpholin-2-ylmethyl)urea

Product 1

HCID 10274401Ethyl {2-[({[(4-chlorophenyl)amino]carbonyl}amino)methyl]morpholin-4-yl}(phenyl)acetateYield 232.3%

Procedure

Example 44 was prepared in an analogous manner to Example 19 using a mixture of Intermediate 9 (0.01 g) and ethyl bromo(phenyl)acetate (0.029 g) to give the title compound (0.0372 g). LC-MS (System A): Rt 3.43 mins, Mass Spectrum m/z 432 [MH+].

Workup

  1. customExample 44 was prepared in an analogous manner to Example 19 using

Sources & evidence

ORD record
ord-575f1b3cad194be6b7f93e221a9a2610
Source dataset
uspto-grants-2007_01
Patent number
US07157457B2

Reaction notes

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