Methanesulfonyl chloride → n-{[(2s)-4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}-n'-{[1-(methylsulfonyl)piperidin-4-yl]methyl}urea

Participants

Reaction Conditions

Reaction Steps

Methane sulphonyl choride (0.013 ml) was added to a solution of Intermediate 18 (0.054 g) and N,N-diisopropylethylamine (0.063 ml) in dichloromethane (2 ml). The solution was stirred for 16 h at 23° C. The solvent was removed in vacuo and the residue purified by solid phase extraction (Isolute SCX sulphonic acid column) eluting with methanol followed by 10% 0.880 ammonia solution in methanol, to give the title compound as a clear gum (0.035 g).

Provenance & Evidence