Methanesulfonyl chloride → n-{[(2s)-4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}-n'-{[1-(methylsulfonyl)piperidin-4-yl]methyl}urea

HRID 1371456Notes

Reaction equation

[CH3:1][S:2](Cl)(=[O:4])=[O:3].Cl.Cl.[Cl:8][C:9]1[CH:10]=[C:11]([CH:31]=[CH:32][C:33]=1[Cl:34])[CH2:12][N:13]1[CH2:18][CH2:17][O:16][C@@H:15]([CH2:19][NH:20][C:21]([NH:23][CH2:24][CH:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[O:22])[CH2:14]1.C(N(CC)C(C)C)(C)C>ClCCl>[Cl:8][C:9]1[CH:10]=[C:11]([CH:31]=[CH:32][C:33]=1[Cl:34])[CH2:12][N:13]1[CH2:18][CH2:17][O:16][C@@H:15]([CH2:19][NH:20][C:21]([NH:23][CH2:24][CH:25]2[CH2:30][CH2:29][N:28]([S:2]([CH3:1])(=[O:4])=[O:3])[CH2:27][CH2:26]2)=[O:22])[CH2:14]1

Participants

Conditions

Temperature: 23 °C

Procedure

Methane sulphonyl choride (0.013 ml) was added to a solution of Intermediate 18 (0.054 g) and N,N-diisopropylethylamine (0.063 ml) in dichloromethane (2 ml). The solution was stirred for 16 h at 23° C. The solvent was removed in vacuo and the residue purified by solid phase extraction (Isolute SCX sulphonic acid column) eluting with methanol followed by 10% 0.880 ammonia solution in methanol, to give the title compound as a clear gum (0.035 g).

Workup

customThe solvent was removed in vacuo
customthe residue purified by solid phase extraction (Isolute SCX sulphonic acid column)
washeluting with methanol

Sources & evidence

ORD record: ord-0c256e7cbc6844368cb96c9e2f7c8605
Source dataset: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07157457B2

Reaction notes

Loading…