Trifluoroacetic acid → HCID 21935985, compound

HRID 1371487Notes

Reaction equation

HRID 1371487 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][O:15][C:16]2[CH:25]=[C:24]3[C:19]([C:20]([NH:26][C:27]4[C:32]([Cl:33])=[CH:31][CH:30]=[C:29]5[O:34][CH2:35][O:36][C:28]=45)=[N:21][CH:22]=[N:23]3)=[CH:18][C:17]=2[O:37][CH3:38])[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>>[ClH:33].[ClH:33].[Cl:33][C:32]1[C:27]([NH:26][C:20]2[C:19]3[C:24](=[CH:25][C:16]([O:15][CH2:14][CH:11]4[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)=[C:17]([O:37][CH3:38])[CH:18]=3)[N:23]=[CH:22][N:21]=2)=[C:28]2[O:36][CH2:35][O:34][C:29]2=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21936076HCID 21936076, compound

Product 1

HCID 21935985HCID 21935985, compound

Procedure

Using an analogous procedure to that described in Example 11, 7-(N-tert-butoxycarbonylpiperidin-4-ylmethoxy)-4-(6-chloro-2,3-methylenedioxyanilino)-6-methoxyquinazoline was reacted with trifluoroacetic acid. The material so obtained was triturated under a 6M solution of hydrogen chloride in diethyl ether. There was thus obtained the title compound; NMR Spectrum: (DMSOd6) 1.5–1.65 (m, 2H), 2.0 (d, 2H), 2.2 (m, 1H), 2.95 (m, 2H), 3.2–3.4 (m, 2H), 4.02 (s, 3H), 4.12 (d, 2H), 6.15 (s, 2H), 7.05 (d, 1H), 7.15 (d, 1H), 7.42 (s, 1H), 8.22 (s, 1H), 8.8 (s, 1H); Mass Spectrum: M+H+ 443 and 445.

Workup

  1. customThe material so obtained
  2. customwas triturated under a 6M solution of hydrogen chloride in diethyl ether

Sources & evidence

ORD record
ord-b21d6767e6ce4fe0b6393e0e9d884151
Source dataset
uspto-grants-2007_01
Patent number
US07157467B2

Reaction notes

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