反应详情

5.7 g 1-(1-Benzyl-piperidin-4-yl)-5-fluoro-2-pentafluoroethyl-1H-benzoimidazole were dissolved in 100 ml methanol and hydrogenated with 2 g Pd/C (10%) at 50° C. and 60 psi for 2 h. The catalyst was removed and the filtrate was evaporated. The residue was crystallized with diisopropyl ether and petrol ether 1:1 to yield 3.9 g beige crystals (mp. 177–178° C.).

1. customThe catalyst was removed
2. customthe filtrate was evaporated
3. customThe residue was crystallized with diisopropyl ether and petrol ether 1:1