HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(1-Benzyl-piperidin-4-yl)-5-fluoro-2-pentafluoroethyl-1H-benzoimidazole → 1-(Piperidin-4-yl)-5-fluoro-2-pentafluoroethyl-1 H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(1-Benzyl-piperidin-4-yl)-5-fluoro-2-pentafluoroethyl-1H-benzoimidazole | HCID 17989657 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(Piperidin-4-yl)-5-fluoro-2-pentafluoroethyl-1 H-benzoimidazole | HCID 17989655 | 86.7% |
Reaction Steps
5.7 g 1-(1-Benzyl-piperidin-4-yl)-5-fluoro-2-pentafluoroethyl-1H-benzoimidazole were dissolved in 100 ml methanol and hydrogenated with 2 g Pd/C (10%) at 50° C. and 60 psi for 2 h. The catalyst was removed and the filtrate was evaporated. The residue was crystallized with diisopropyl ether and petrol ether 1:1 to yield 3.9 g beige crystals (mp. 177–178° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157471B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-8acd6fef4b4545598c7ea5d270b38fdc |
| Source note | uspto-grants-2007_01 |