4-Amino-2-(ethylthio)pyrimidine-5-carboxylic acid → (4-Amino-2-ethylsulfanyl-pyrimidin-5-yl)-(2,6-difluoro-3-methoxy-phenyl)-methanone

HRID 1371637Notes

Reaction equation

HRID 1371637 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([OH:10])=O)=[CH:6][N:5]=[C:4]([S:11][CH2:12][CH3:13])[N:3]=1.Br[C:15]1[CH:20]=[C:19]([F:21])[CH:18]=[C:17]([F:22])[C:16]=1[O:23][CH3:24]>>[NH2:1][C:2]1[C:7]([C:8]([C:18]2[C:19]([F:21])=[CH:20][CH:15]=[C:16]([O:23][CH3:24])[C:17]=2[F:22])=[O:10])=[CH:6][N:5]=[C:4]([S:11][CH2:12][CH3:13])[N:3]=1

Participants

3

Reactant 2

HCID 2753004-Amino-2-(ethylthio)pyrimidine-5-carboxylic acidHCID 27362632-Bromo-4,6-difluoroanisole

Product 1

HCID 21070573(4-Amino-2-ethylsulfanyl-pyrimidin-5-yl)-(2,6-difluoro-3-methoxy-phenyl)-methanone

Procedure

The same procedure as described in Example 47 was used, starting from 4-amino-2-ethylsulfanylpyrimidine-5-carboxylic acid, Example 1, and 2-bromo-4,6-difluoroanisole (Astatech), to give (4-amino-2-ethylsulfanyl-pyrimidin-5-yl)-(2,6-difluoro-3-methoxy-phenyl)-methanone as a white solid. MS (M+H)+, 326.

Sources & evidence

ORD record
ord-6954454c61e04ec192ae92af7f41ee31
Source dataset
uspto-grants-2007_01
Patent number
US07157455B2

Reaction notes

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