HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-2-(ethylthio)pyrimidine-5-carboxylic acid → (4-Amino-2-ethylsulfanyl-pyrimidin-5-yl)-(2,6-difluoro-3-methoxy-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-2-(ethylthio)pyrimidine-5-carboxylic acid | HCID 275300 | — |
| Reactant | 2-Bromo-4,6-difluoroanisole | HCID 2736263 | — |
| Product | (4-Amino-2-ethylsulfanyl-pyrimidin-5-yl)-(2,6-difluoro-3-methoxy-phenyl)-methanone | HCID 21070573 | — |
Reaction Steps
The same procedure as described in Example 47 was used, starting from 4-amino-2-ethylsulfanylpyrimidine-5-carboxylic acid, Example 1, and 2-bromo-4,6-difluoroanisole (Astatech), to give (4-amino-2-ethylsulfanyl-pyrimidin-5-yl)-(2,6-difluoro-3-methoxy-phenyl)-methanone as a white solid. MS (M+H)+, 326.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07157455B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-6954454c61e04ec192ae92af7f41ee31 |
| Source note | uspto-grants-2007_01 |