N-[cis-4-(Boc-amino)cyclohexyl]methanesulfonamide → HCID 86760349, compound

HRID 1371650Notes

Reaction equation

HRID 1371650 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][CH:11]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])[CH2:10][CH2:9]1)(C)(C)C.[F:20][C:21]([F:26])([F:25])[C:22]([OH:24])=[O:23].ClCCl>>[F:20][C:21]([F:26])([F:25])[C:22]([OH:24])=[O:23].[NH2:7][CH:8]1[CH2:13][CH2:12][CH:11]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 18348373N-[cis-4-(Boc-amino)cyclohexyl]methanesulfonamideHCID 21863450Trifluoroacetic acid methylene chloride

Product 1

HCID 86760349HCID 86760349, compound

Procedure

The compound obtained from step A was dissolved in 50% trifluoroacetic acid/dichloromethane and the mixture was stirred at room temperature for 30 minutes. The excess acid was removed under reduced pressure and the residue was triturated with ether to give a white powder, 1.51 g, 90% for two steps. MS(ES) (M+H)+=193.

Workup

  1. customThe excess acid was removed under reduced pressure
  2. customthe residue was triturated with ether
  3. customto give a white powder, 1.51 g, 90% for two steps

Sources & evidence

ORD record
ord-33ff2f8605b44c0298d12b419206300d
Source dataset
uspto-grants-2007_01
Patent number
US07157455B2

Reaction notes

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