2-Thiophenecarboxylic acid, 3-(chlorosulfonyl)-, methyl ester → 3-[4-[4-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyrimidin-2-ylamino]-piperidine-1-sulfonyl]-thiophene-2-carboxylic acid methyl ester

HRID 1371660Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1371660
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[O:17][CH3:18])=[O:9])=[CH:6][N:5]=[C:4]([NH:19][CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[N:3]=1.[C:26]([C:30]1[S:31][CH:32]=[CH:33][C:34]=1[S:35](Cl)(=[O:37])=[O:36])([O:28][CH3:29])=[O:27]>>[CH3:29][O:28][C:26]([C:30]1[S:31][CH:32]=[CH:33][C:34]=1[S:35]([N:23]1[CH2:22][CH2:21][CH:20]([NH:19][C:4]2[N:3]=[C:2]([NH2:1])[C:7]([C:8](=[O:9])[C:10]3[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=3[O:17][CH3:18])=[CH:6][N:5]=2)[CH2:25][CH2:24]1)(=[O:37])=[O:36])=[O:27]

Komponenten

3

Edukt 2

HCID 27367332-Thiophenecarboxylic acid, 3-(chlorosulfonyl)-, methyl esterHCID 9997668[4-Amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone

Produkt 1

HCID 587776313-[4-[4-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyrimidin-2-ylamino]-piperidine-1-sulfonyl]-thiophene-2-carboxylic acid methyl ester

Versuchsvorschrift

This compound was prepared from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone, Example 59, and 2-carbomethoxy-3-thiophenesulfonyl chloride (Maybridge) by the procedure described in Example 152. HR-MS (ES, m/z) calculated for C23H25FN5O6S2 [(M+H)+] 550.1225, observed 550.1232.

Quellen und Nachweise

ORD-Eintrag
ord-497ee110a85944bab157f141d4771b26
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07157455B2

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