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HRID 1371660作成日：2026年10月25日

2-Thiophenecarboxylic acid, 3-(chlorosulfonyl)-, methyl ester → 3-[4-[4-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyrimidin-2-ylamino]-piperidine-1-sulfonyl]-thiophene-2-carboxylic acid methyl ester

https://huagongshe.com/reaction/1371660

反応式

関与物質

役割名称HCID仕込み量
反応物2-Thiophenecarboxylic acid, 3-(chlorosulfonyl)-, methyl esterHCID 2736733—
反応物[4-Amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanoneHCID 9997668—
生成物3-[4-[4-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyrimidin-2-ylamino]-piperidine-1-sulfonyl]-thiophene-2-carboxylic acid methyl esterHCID 58777631—

反応手順

This compound was prepared from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone, Example 59, and 2-carbomethoxy-3-thiophenesulfonyl chloride (Maybridge) by the procedure described in Example 152. HR-MS (ES, m/z) calculated for C23H25FN5O6S2 [(M+H)+] 550.1225, observed 550.1232.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07157455B2
出典データセットuspto-grants-2007_01
ORD IDord-497ee110a85944bab157f141d4771b26
出典メモuspto-grants-2007_01