1,2-Difluoro-4,5-dimethoxybenzene → HCID 21070607, compound

HRID 1371724Notes

Reaction equation

HRID 1371724 reaction equation
CON(C)[C:4]([C:6]1[C:7]([NH2:14])=[N:8][C:9]([S:12][CH3:13])=[N:10][CH:11]=1)=[O:5].[F:16][C:17]1[CH:22]=[C:21]([O:23][CH3:24])[C:20]([O:25][CH3:26])=[CH:19][C:18]=1[F:27]>>[NH2:14][C:7]1[C:6]([C:4]([C:22]2[C:21]([O:23][CH3:24])=[C:20]([O:25][CH3:26])[CH:19]=[C:18]([F:27])[C:17]=2[F:16])=[O:5])=[CH:11][N:10]=[C:9]([S:12][CH3:13])[N:8]=1

Participants

3

Reactant 2

HCID 8531751,2-Difluoro-4,5-dimethoxybenzeneHCID 587775474-Amino-N-methoxy-N-methyl-2-(methylsulfanyl)pyrimidine-5-carboxamide

Product 1

HCID 21070607HCID 21070607, compound

Procedure

The compound was prepared from 4-amino-2-methylsulfanyl-pyrimidine-5-carboxylic acid methoxy-methyl-amide (Example 168) and 1,2-difluoro-4,5-dimethoxy-benzene (Aldrich) in an analogous manner as described in Example 169. HR-MS (ES, m/z) calculated for C14H14N3O3SF2 (M+) 341.0646, observed 341.0644.

Sources & evidence

ORD record
ord-9ec6d10901f4473f8df239081864bfee
Source dataset
uspto-grants-2007_01
Patent number
US07157455B2

Reaction notes

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