HCID 21070508, compound → HCID 21070509, compound

HRID 1371747Notes

Reaction equation

HRID 1371747 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([CH:9]([C:11]2[C:19]3[O:18][CH:17]=[CH:16][C:15]=3[CH:14]=[C:13]([F:20])[CH:12]=2)[OH:10])=[CH:4][N:3]=1>C(OC(=O)C)C.[O-2].[Mn+2]>[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([C:9]([C:11]2[C:19]3[O:18][CH:17]=[CH:16][C:15]=3[CH:14]=[C:13]([F:20])[CH:12]=2)=[O:10])=[CH:4][N:3]=1

Participants

4

Reactant 1

HCID 21070508HCID 21070508, compound

Product 1

HCID 21070509HCID 21070509, compoundYield 908.9%

Reagents, catalysts & solvents 2

HCID 160959Manganese oxideCatalystHCID 8857Ethyl AcetateSolvent2×

Procedure

At 20° C., a solution of (2,4-dichloro-pyrimidin-5-yl)-(5-fluoro-benzofuran-7-yl)-methanol (0.9 g, 0.29 mmol, Step D) in ethylacetate (110 mL) was treated with a slurry of manganese oxide (9.0 g, Aldrich) in ethyl acetate (110 mL). After stirring for 3.5 hours, the reaction was filtered through celite and solvent removed in vacuo to give 0.82 g of (2,4-dichloro-pyrimidin-5-yl)-(5-fluoro-benzofuran-7-yl)-methanone as a foam and taken to the next step.

Workup

  1. filtrationthe reaction was filtered through celite and solvent
  2. customremoved in vacuo

Sources & evidence

ORD record
ord-989467eba7fd4ff9b7c03ab1b1017ec3
Source dataset
uspto-grants-2007_01
Patent number
US07157455B2

Reaction notes

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