反应详情

温度

84 °C

To a stirred solution of the bromide (70 mg, 0.27 mmol, Example 307) in dimethylformamide (3 mL), sodium azide (80 mg, 1.23 mmol) was added and the mixture was stirred at 84° C. overnight. The solvent was removed and the residue was chromatographed (50% ethyl acetate/hexane) to give the desired product as a colorless oil. 51 mg, 86%. H1NMR (300 MHz, CDCl3), ppm: 1.60–1.70 (m), 1H; 2.05–2.20(m), 1H; 2.80–3.05 (m), 2H; 2.83 (s), 3H; 3.10 (br), 1H (OH); 3.40–3.51 (m), 1H; 3.51–3.62 (m), 1H. 3.65–3.80 (m), 2H.

1. customThe solvent was removed
2. customthe residue was chromatographed (50% ethyl acetate/hexane)